Introduction: Helicobacter pylori infection is one of the commonest bacterial infections in human world-wide. H.pylori is a significant cause of a number of intra-digestive and extra-digestive disorders with increased prevalence in the developing countries.
Objectives: This study investigated the relationship between platelet count and peptic ulcer and also compared the results of the test subjects with the controls.
Methodology: Sixty subjects (age: 27.5±3.2) were enrolled for the study which included forty newly diagnosed peptic ulcer patients from the Medical Outpatient Clinic of a tertiary health institution in Ogun State, Nigeria and twenty age-matched, apparently healthy individuals from the same geographical location were selected as controls. Platelet count analysis was done with BC-5300 Auto Haematology analyzer and the detection of serum H.pylori antibodies was done using diaspot rapid chromatographic immunoassay method. Data obtained were statistically analysed using ANOVA, Post-Hoc and Pearson’s correlation. P<0> Results: The platelet count was significantly low in H.pylori infected peptic ulcer subjects when compared with both H.pylori negative peptic ulcer subjects and controls (p<0> Conclusion: The study concluded that, not all cases of peptic ulcer are associated with thrombocytopenia however, thrombocytopenia in peptic ulcer subjects, is solely associated with H.pylori infection.