Coffee attenuates induction of insulin resistance in high-sucrose fed rats

Coffee attenuates induction of insulin resistance in high-sucrose fed rats

Author by Ayodele Olufemi Morakinyo

Journal/Publisher: Nigerian Journal Of Physiological Sciences

Volume/Edition: 28

Language: English

Pages: 179 - 185

Abstract

Several epidemiological evidences indicate that consumption of coffee is associated with a lower risk of type 2 diabetes mellitus (T2DM) however; there is dearth of experimental data to support these observations. Given that associations do not necessarily infer causality, the present study was designed to investigate the effect of coffee consumption on glucose regulation, T2DM and the probable mechanisms of action, using an animal model. The effect of coffee (2-fold dilution) by oral gavage on normal and high sucrose-solution (HSS) fed (30 % w/v) rats was evaluated. The results showed that consumption of coffee significantly increase glucose tolerance and insulin sensitivity (p<0>


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