Antioxidant and oxidative stress status in human plasmodium malaria.

Antioxidant and oxidative stress status in human plasmodium malaria.

Author by I.o. Oyewole

Journal/Publisher: Der Pharmacia Lettre

Volume/Edition: 3

Language: English

Pages: 91 - 96

Abstract

The present study investigated the protective state of endogenous antioxidants against free
radicals generated in human plasmodium malaria. Two hundred structured questionnaires
were administered to the participants and blood samples were collected to assess the
activities of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST)
and reduced glutathione (GSH). Results showed that the 200 volunteered participants, 32%
(73) and 68% (127) were males and females respectively. There was discrepancy in the
number of male (12%) and female (31%) respondents in the low oxidative stress category as
well as in the moderate oxidative stress category where 69% were females and 84% were
males. However, in the high oxidative stress category 4% of the observed respondents were
males. All participants tested were positive for parasitaemia and categorized as high and low
parasitaemic patients. Qualitative examinations of the impact of malaria showed that 30%,
67% and 3% high parasitaemic patients exhibited low, medium and high oxidative stress
respectively while 55%, 45% and 0% low parasitaemic patients demonstrated low, medium
and high oxidative stress respectively. Furthermore, there were significant elevation
(P<0> S-transferase activities in the low parasitaemic patients compared to the high parasitaemic
groups. However, there was no significant difference (P>0.05) in the level of glutathione and
catalase activity between high and low parasitaemic patients. This study indicates that high
parasitaemic patients are at greater risk of oxidative damage than low parasitaemic group,
hence early diagnosis and treatment of malaria is highly encouraged.


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