Toxicological effects of hospital wastewater using animal bioassays

Toxicological effects of hospital wastewater using animal bioassays

Author by Dr. Olutayo Shokunbi

Journal/Publisher: Annals Of Biological Research

Volume/Edition: 2

Language: English

Pages: 265 - 275

Abstract

Hospitals represent an incontestable release source of many chemical compounds in the environment due to
laboratory activity or medicine excretion into wastewater. The present study therefore, focused on the toxicological
and genotoxic evaluation of hospital wastewater using animal bioassays: Micronucleus (MN), Chromosome
aberration (CA), Sperm morphology assays and sperm mean count. Physico-chemical and heavy metal analyses of
the wastewater were carried out. Mice were given 0.5ml intraperitoneal injection of 1%, 5%, 10%, 25% and 50%
concentrations (v/v) of the wastewater and sacrificed as appriopriate. The difference between the negative control,
positive control and the individual dose groups were analyzed by means of the students t-test of significance at the
p<0> that are capable of inducing mutation in biological system. The data showed that the hospital wastewater is
genotoxic, inducing a dose-dependent, statistically significant (p<0> aberration and sperms with abnormal morphology with observed decrease in mean sperm count. Hospital waste
poses a significant impact on health and environment, therefore proper waste management strategy is needed to
ensure health and environmental safety.


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