Coartemether in dietary oil induces oxidative stress and hepatotoxicity

Coartemether in dietary oil induces oxidative stress and hepatotoxicity

Author by Dr. Godswill Anyasor

Journal/Publisher: Researcher

Volume/Edition: 3

Language: English

Pages: 35 - 41

Abstract

Lipid rich diet enhances the bioavailability and therapeutic potency of coartemether (artemetherlumefantrine),
an ACT antimalarial drug. However, its impact on the coartemether cytotoxicity has stimulated this
investigation. Thus, this study evaluated the in vivo effect of coartemether in the presence of oil on the antioxidant
and hepatotoxic biomarkers in albino rats for 3 days. Twenty (20) rats were randomly divided into four groups of
five rats per group. Group I (control) received normal placebo saline (0.9% NaCl), group II (C) was treated with
coartemether (4 mg artemether: 24 mg lumefantrine), group III (O) received sunflower oil (1.0 ml) and group IV (CO)
was co-administered coartemether (4 mg artemether: 24 mg lumefantrine) and (1.0 ml sunflower oil). Result
showed no significant difference (P>0.05) in SOD and GSH levels in all treated groups compared to control while
there was a significant (P<0> animals compared to other treatment groups. The C-O treated animals had significantly (P<0> heart GST activity compared with other groups. Coartemether treated animals had an elevated plasma
malondialdehyde content which was reversed in C-O group. Furthermore, coartemether and C-O treated groups had
elevated alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase levels compared with the
control animals. However, bilirubin levels were high and low in coartemether and C-O treated groups respectively.
Therefore, investigation from this study shows that coartemether in an oil medium could induce oxidative stress and
hepatotoxic biomarkers.
[Anyasor God’swill Nduka, Odunsanya Olutayo Tolulope. Coartemether in Dietary Oil Induces Oxidative Stress
and Hepatotoxicity in Albino Rat. Researcher. 2011;3(7):35-41]. (ISSN: 1553-9865). http://www.sciencepub.net.


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