Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice.

Coartemether induced oxidative stress and hepatic damage in Plasmodium berghei Strain Anka infected mice.

Author by Dr. Godswill Anyasor

Journal/Publisher: Bulletin On Environmental Contamination And Toxicology

Volume/Edition: 88

Language: English

Pages: 108 - 111

Abstract

This study investigated the effect of coartemether
on antioxidant and hepatotoxic biomarkers in Plasmodium
berghei infected mice. Erythrocyte, hepatic and
renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87;
2.84 ± 0.22 Units/mg protein respectively) and catalase
(4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein
respectively) activities were significantly (p\0.05) elevated
in ‘‘parasitized and treated’’ (PnT) animals. Renal
glutathione level (19.02 ± 0.20 lg/mL) was elevated in
PnT animals. Glutathione S-transferase and malondialdehyde
levels in hepatic (8.76 ± 0.49 lmol/min/mg; 527.23 ±
24.56 mmol/dL) and renal (3.35 ± 0.30 lmol/min/mg;
464.42 ± 59.13 mmol/dL) tissues were significantly high
(p\0.05) in coartemether-treated animals alone. Plasma
aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase
(5.78 ± 2.36 U/L) were high in PnT animals. Therefore,
data indicates that in the presence of P. berghei,
coartemether could alter the antioxidant status and induce
hepatotoxic damage in mice.


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