Hexane fraction of Costus afer Ker Gawl. Leaves inhibited mitochondrial membrane permeability transition, F1F0 ATPase and scavenged nitric oxide and hydrogen peroxide.

Hexane fraction of Costus afer Ker Gawl. Leaves inhibited mitochondrial membrane permeability transition, F1F0 ATPase and scavenged nitric oxide and hydrogen peroxide.

Author by Prof. Godswill Anyasor

Journal/Publisher: Journal Of Investigational Biochemistry

Volume/Edition: 3

Language: English

Pages: 78 - 84

Abstract

Introduction: Costus afer ker Gawl. is an indigenous medicinal plant used as therapy in the treatment of inflammatory disease like rheumatoid arthritis. Objective: This study was designed to investigate the chemoprotective potentials of the hexane fraction of C. afer leaves (CAHLF) on some biochemical biomarkers such as mitochondrial membrane permeability transition (MPT), F1F0 adenosine triphosphatase (ATPase), nitric oxide (NO•) and hydrogen peroxide (H2O2) activities using spectrophotometric methods. Results: Results showed that isolated mitochondria fractions from normal rats preloaded with 10-60 ?g/ml CAHLF significantly (P < 0>


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