Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice.

Oral administered ascorbic acid attenuated dihydroartemisinin anti-plasmodial activity and elicited hepatic injury in Plasmodium berghei strain Anka infected mice.

Author by Dr. Godswill Anyasor

Journal/Publisher: Journal Of Experimental And Integrative Medicine

Volume/Edition: 6

Language: English

Pages: 139 - 142

Abstract

Objective: This study investigated the effects of oral co-administered ascorbic acid (AA) and dihydroartemisinin (DHA) on
some hepatotoxic biomarkers and parasitaemia counts in Plasmodium berghei Anka strain infected mice for 7 d.
Methods: Twenty four male Swiss albino mice were randomly distributed into six groups; group I: “non-parasitized and
non-treated”(nPnT), group II: “parasitized and non-treated”(PnT), group III: parasitized mice administered 5 mg/kg DHA,
group IV: parasitized mice administered 5 mg/kg AA, group V: parasitized mice co-administered 5 mg/kg DHA+ 5 mg/kg
AA and group VI: parasitized mice administered 25 mg/kg chloroquine (CQ) as standard.
Results: Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly (P<0> reduced in AA, DHA and CQ treated mice compared with PnT mice respectively. In addition, parasitized mice co-treated
with DHA+AA had elevated plasma ALT and AST activities compared with DHA treated mice. Further investigation showed
that parasite count/?l blood in PnT, AA and AA+DHA were not significantly (P>0.05) different. However, DHA and CQ
treated mice had significantly reduced parasite count/?l blood at P<0> Conclusion: Thus, data from this study indicated that the AA interferes with the


Other Co-Authors