Gastroprotective and antioxidant activities of Phyllanthus amarus extracts on absolute ethanolinduced ulcer in albino rats

Gastroprotective and antioxidant activities of Phyllanthus amarus extracts on absolute ethanolinduced ulcer in albino rats

Author by Dr. Olutayo Shokunbi

Journal/Publisher: Journal Of Medicinal Plants Research

Volume/Edition: 2

Language: English

Pages: 261 - 267

Abstract

This study was designed to evaluate the gastroprotective and antioxidant effects of aqueous and
acetone extracts of Phyllanthus amarus leaves in albino rats. P. amarus extracts (500 and 1000 mg/Kg)
as well as cimetidine (100 mg/Kg) was administered orally once a day for two weeks before challenge
with absolute ethanol (1 ml/ 200 g body wt). Pretreatment with P. amarus aqueous extract (500 mg/Kg)
and cimetidine inhibited the ulceration damage of absolute ethanol by 59.3 and 41.2% and decreased
the serum alanine aminotransferase (ALT) by 35%, 24% and aspartate aminotransferase (AST) by 7 and
6% respectively. The acetone extract (1000 mg/Kg) also significantly increased (P < 0> ethanol mediated decrease in the activities of gastric mucosal catalase (CAT), superoxide dismutase
(SOD) and glutathione-s-transferase (GST) by 53, 8 and 33% respectively. Cimetidine respectively
caused 52, 14 and 38% significant (P< 0> activities of CAT, SOD and GST. Furthermore, P. amarus aqueous extract (500 mg/Kg) and cimetidine
were noted to increase the activities of liver CAT by 18 and 20%, SOD by 25 and 19% and GST by 122
and 54% respectively. However, the liver thiobarbituric acid reacting substances (TBARS) values of all
the groups pretreated with P. amarus extracts and cimetidine were not significantly different (P < 0> from the ethanol group. In this study, P. amarus extracts appears to act as an in vivo natural antioxidant
and an effective gastroprotective agent that is as effective as cimetidine. P. amarus may also offer
protection against toxic effects of alcohol to the liver.


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