One of the clinical significance of the sella turcica is the empty sella syndrome which is the condition of a shrunken or flattened pituitary gland; hence a familiarity with the sella turcica anatomy and radiological appearance is of great importance. The present study investigated the normal dimensions of the sella turcica and the relationship with gender and age in adult Nigerians resident in Lagos, using computed tomographs of patients who underwent CT head examination. This was carried out to determine if the dimensions of sella turcica vary with age, gender and race; this is with a view to providing normal, standard reference for the indigenous population in Nigeria. This study assessed: the length, the depth and the anteroposterior diameter of the sella turcica; 297 samples were obtained and analyzed using SPSS Windows Version 14.0. T- test was used for the statistical analysis and values obtained were expressed as mean±S.E.M. and P value ? 0.05 was considered statistically significant. The results showed the mean length of 9.81±0.094mm; the mean antero-posterior diameter of 11.37±0.090mm and the mean depth of 8.49±0.08mm. It was also observed that neither the age group nor the gender of the patients is a determinant of the sella turcica dimensions. Furthermore, the males tend to have slightly larger sella turcica dimensions than the females and the values from the present study are lower than those reported in Caucasian studies. The size of pituitary gland can be roughly estimated from the dimensions of sella turcica obtained from radiological methods in pathological conditions since disease conditions of the “master gland” ultimately affect the size of the sella turcica.