An experiment was conducted with 36 crossbred rabbits (49 days old) averaging 650 ± 0.50 to assess the serum biochemical response and organ histopathology of growing rabbits fed graded levels of whole kenaf seed meal (WKSM) of 0%, 20%, 40%.60%.80% and 100% as a replacement of soya bean meal (SBM). Blood samples were collected from the animals through the ear vein, while samples of organ were collected from the animals after the feeding trials. Results showed that the serum protein examined were not significantly (p<0>