AMELIORATIVE EFFECTS OF PROGESTERONE ON PREFRONTAL CORTEX PLAQUES AND NEUROFIBRILLARY TANGLES ASSOCIATED WITH STREPTOZOTOCIN-INDUCED DIABETIC RATS BRAIN

AMELIORATIVE EFFECTS OF PROGESTERONE ON PREFRONTAL CORTEX PLAQUES AND NEUROFIBRILLARY TANGLES ASSOCIATED WITH STREPTOZOTOCIN-INDUCED DIABETIC RATS BRAIN

Author by Mr. Opeyemi Debola Adetunji

Journal/Publisher: Global Scientific Journal

Volume/Edition: 6

Language: English

Pages: 1 - 1

Abstract

Progesterone, secreted and synthesized by nerve tissues has been implicated in brain functions, such as its neuroprotective and regenerative potentials on the damaged neurons. This study seeks to evaluate the therapeutic potentials of progesterone on the microanatomy of the prefrontal cortex (PFC) in streptozotocin-induced diabetic rats’ brain. Forty eight (48) male Wistar rats with an average weight of 225g±5 was used for a duration of 16 weeks. The rats were divided into 6 groups comprising of 8 rats each. To induce diabetes; 30 mg/kg body weight of Streptozotocin was injected intraperitoneally along with an oil vehicle of 0.1ml of citrate buffer solution at pH of 4.5. Groups A served as the control, received 1ml of distilled water, group B received 4 mg/kg/body weight/day of progesterone injection intraperitoneally, group C received 8 mg/kg/body weight/day of progesterone injection intraperitoneally, group D recieved double doses of 30 mg/kg body weight/day of Streptozotocin intraperitoneally, group E received double doses of 30 mg/kg body weight/day of Streptozotocin and 4 mg/kg/body weight/day of progesterone injection intraperitoneally and group F received double doses of 30 mg/kg body weight/day of Streptozotocin and 4 mg/kg/body weight/day of progesterone injection intraperitoneally. Blood glucose levels and histological studies of the Prefrontal cortex of the rats brain was analyzed. Increase in consumption of food, water, and glucose levels was observed in the diabetic animals when compared with control. Body weight decreased in the diabetic animals when compared with control while histological analysis in group D showed the presence of plaques and multiple neurofibrillary tangles in the polymorphic, pyramidal and molecular layers of the cortex while a dose dependent signicant decrease (P<0>


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