Effect of traditional diets on oxidative stress and lipid profile of alloxan induced diabetic rats

Effect of traditional diets on oxidative stress and lipid profile of alloxan induced diabetic rats

Author by Dr. Ime Ani

Journal/Publisher: African Journal Of Food Science

Volume/Edition: 5

Language: English

Pages: 143 - 147

Abstract

The objective of this study was to compare the effect of recommended diet namely, plantain porridge

and beans with other traditional Nigerian diets on oxidative stress and lipid profile in alloxan diabetic

rats. Therefore, in the design, six groups (1 non diabetic and 5 diabetic) of 7 rats each, were accordingly

treated: the normal and diabetic controls were fed normal rat pellets; garri with afang soup, pounded

yam with edikang ikong soup, ekpang nkukwo, and the control diet (plantain porridge with beans)

respectively, were fed to the other diabetic groups. The diets and water were given ad libitium and this

lasted for 15 days after which biochemical indices of oxidative stress and lipid profile were respectively

determined in liver homogenates and serum of the experimental animals. Superoxide dismutase (SOD)

activity significantly increased (p<0>

increase was highest in the control diet, it was not significant (p>0.05) with respect to the traditional

diets. The reverse was the case with Glutathione peroxidase (GPx) activity, which was significantly

decreased in the control diet compared to the traditional diets and diabetic control. Yet the extent of

lipid peroxidation (malondialdehyde, MDA) was seen to be highest in the control diet. The effects of the

traditional diets and the control diet on lipid profile were similar. These traditional diets could be more

effective in amelioration of oxidative stress in dietary management of diabetes mellitus


Other Co-Authors