An Assessment of Renal Function Parameters on the Ameliorative Properties of Ginkgo Biloba Extract

An Assessment of Renal Function Parameters on the Ameliorative Properties of Ginkgo Biloba Extract

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Journal/Publisher: American Journal Of Clinical And Experimental Medicine

Volume/Edition: 4

Language: English

Pages: 112 - 117

Abstract

 Renal failure is a growing concern in the modern society and the increasing rate of exposure to toxic substances has contributed a lot to renal diseases. As a result of this, there is a great need for agents that can serve as nephroprotective. The present study assessed some parameters of renal function on the ameliorative properties of Ginkgo biloba extract (GBE) in cadmium (Cd) - induced nephrotoxicity in adult wistar rats model. The study was performed on twenty four (24) male Wistar rats divided into four groups: Group A (Control), Group B (Cd), Group C (Cd + 100mg/kg BW of GBE) and Group D (Cd + 300mg/kg BW of GBE). The Cd and GBE were administered orally through oro-gastric cannula. The results showed changes in the renal function chemical parameters (creatinine, urea, and total protein) in the treated groups compared to the control group. Exposure to Cd lowered the activities of the kidney by increasing the plasma level of creatinine and urea, and decreasing the plasma level of total protein. The creatinine concentration decreased significantly (p<0>


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