Methanolic Extract of Musa Sapientum Sucker Proffers Antioxidant Effect against Indomethacin-induced Ulceration Oxidative Stress in Wistar Rats.

Methanolic Extract of Musa Sapientum Sucker Proffers Antioxidant Effect against Indomethacin-induced Ulceration Oxidative Stress in Wistar Rats.

Author by Mr. Oluwafemi Kale

Journal/Publisher: Iosr Journal Of Pharmacy And Biological Sciences (iosr-jpbs)

Volume/Edition: 8

Language: English

Pages: 7 - 12

Abstract

Effect of methanolic extract of musa sapientum sucker (MEMSS) in indomethacin-induced ulceration in Wistar rats was investigated. Thirty albino rats (120-150 g) were divided into six groups. Negative and positive control rats (group 1 and 2) received no treatment and indomethacin (50 mg/kg) respectively. Group 3 rats received Omeprazole (0.8 mg/kg) 4 hours following indomethacin (50 mg/kg) intoxication. Groups 4, 5, and 6 received 5 mg/kg, 10 mg/kg and 20 mg/kg of MEMSS respectively 4 hour after indomethacin (50 mg/kg) induction. Treatment last for fourteen days and dosing was via oral route. Rats were anaesthetized and sacrificed 24 hours following last treatment. In our results, we scored ulcer induction by indomethacin using elevated biomarker enzymes. Indomethacin (50 mg/kg) administered alone increased (p< 0>


Other Co-Authors