In the quest to determine the psychosocial wellbeing of terminal disease patients in Nigeria, this study examined the psychosocial adjustment and counselling for terminal disease patients and the role played by the family, caregivers, social network and the patients themselves in their adjustment to living and management of dying. Three research questions were conjectured: (l) what would be the interactive effect of the psychosocial variables on the psychosocial adjustment of terminal disease patients? (ii) What would be the relative effect of the prediction variables on the criterion variables? (in) Would there be any significant difference in the psychosocial adjustment of patients based on their mode of receiving treatment? The expost -facto research design was adopted for this study. Eighty-three patients (51 and 32 HIV/AIDS and cancer patients respectively) volunteered themselves for this study. Data were collected through structured interview/questionnaire and were analyzed using the simple percentages, multiple regression and Z-test statistical tools of SPSS packages. Results tested at 0.05 level of significance indicated that (i) Psychosocial factors significantly affect the psychosocial adjustment of patients; (ii) Each of the prediction variables significantly affects the patients' psychosocial adjustment; and (Hi) a significant difference was observed between the psychosocial adjustment of patients stationed at the clinic and those coming from home for their treatment. On the basis of the findings, it was suggested that human adjustment in sickness to a large extent depend on the support derived from the family, friends, medical practitioners and factors like moral and financial support.