Histopathological Degeneration of Spermatogenesis and Histomorphometric Alterations of the T esticularMicroanatomy of Male WistarRats afterOral Lead Intoxication

Histopathological Degeneration of Spermatogenesis and Histomorphometric Alterations of the T esticularMicroanatomy of Male WistarRats afterOral Lead Intoxication

Author by Mr. Opeyemi Adebola Adetunji

Journal/Publisher: Journal Of Krishna Institute Of Medical Sciences University

Volume/Edition: 8

Language: English

Pages: 1 - 8

Abstract

Backgr ound:  Lead  is  a  heavy  metal  known  to  exert pathological  effects  on  the  male  reproductive  organs. Aim  and  Objectives:  To  study  the  degeneration  of spermatogenesis and histomorphometric alterations of the  testicular  microanatomy  of  male  Wistar  rats  after oral  lead  intoxication.  Material  and  Methods:  Eighty male Wistar  rats  were  divided into four  groups  (1-  4) and further subdivided into 4 subgroups (A, B, C, and D)  each  containing  five  (n=5)  rats  depending  on  dosage and  duration  (3,  6,  9  and  12  weeks)  of  treatment.  Group 1  received  1  ml  of  distilled  water  daily .  Group  2 received  0.5%  lead  daily ,  Group  3  received  1.0%  of lead  daily  and  Group  4  received  1.5%  of  lead  daily respectively .  Testicular  weights,  histomorphometry and  histological  analysis  using  T oluidine  Blue  were observed.  Results:  It  showed  that  significant  reductions (P<0> Keywords: Lead,  testis,  Gonadotoxic, Histomorphometry,  Spermatogenesis


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