Context: Progestogen?only injectable contraceptive is a long-lasting contraceptive given at interval of two or 3 months. It is effective, safe and convenient. Menstrual irregularity is a recognised side effect. Aims: This study aims to determine the acceptor prevalence and clinical experience of women using progestogen?only injectable contraceptive at Olabisi Onabanjo University Teaching Hospital, Sagamu. Methods: This was a retrospective study of new acceptors of progestogen?only injectable contraceptives between 1 January, 2010, and 31 December, 2014. Relevant information was retrieved from the family planning clinic records using a purpose-designed data capture sheet. Data analysis was done using IBM-SPSS windows version 21. Results: Out of a total of 623 new acceptors of contraceptives during the study period, 162 opted for progestogen?only injectable contraceptives giving an acceptor prevalence of 26%. The mean age of new acceptors was 32.69 ± 5.94 years. Majority 108 (66.7%) used depot medroxyprogesterone acetate. Child spacing was the most common indication for use. Ninety-seven clients(59.9%) had not used any previous contraceptive method. Menstrual irregularity was the most common side effect, occurring in 73 (45.1%) of the clients. Continuation rate after the fifth dose was 27.1%. No pregnancy complication was reported. Conclusions: Acceptor prevalence and continuation rate of progestogen?only injectable contraceptive are low. There is need for more enlightenment campaigns to encourage women to use this effective method of contraception.