Effects of a Type V Phosphodiesterase Inhibitor (Tadalafil) On Indomethacin-Induced Gastric Ulceration in Rats.

Effects of a Type V Phosphodiesterase Inhibitor (Tadalafil) On Indomethacin-Induced Gastric Ulceration in Rats.

Author by Dr. Kolawole Ajiboye

Journal/Publisher: International Journal Of Tropical Medicine

Volume/Edition: 7

Language: English

Pages: 111 - 116

Abstract

Gastric ulcer is one of the most prevalent gastrointestinal disorders and still remains a major on-going
health concern. Phosphodiesterase V inhibitors (P DE V) are drugs currently used m the treatment of patients
with erectile dysfunction and pulmonary hypertension. They act by Increasmg blood flow to tissues in
response to Increased cGlv1P levels. They are also Nitric Oxide (NO) donors. NO is a potent vasodilator which
Increases blood flow in tissues where present thus preventing tissue damage. This study therefore exammed
the effects Tadalafil (TAD) on Indomethacm-induced gastric ulceration m rats. Three studies were directed at
exammmg the effects of Tadalafil on gastric ulceration, ulcer dimensions and histological profile m
indomethacm-induced rats. Male Wistar Albino rats weighing between 180-220 g were used. Each experimental
group containing 6 rats were divided based on the following pre-treatments: Group I (Control)-saline
(8 mL kg¯ ), Group II-IV were pre-treated with graded doses of Tadalafil (2, 5 and 10 mg kg¯l body weight,
respectively), Group V (Reference)-Cimet1dine 100 mg kg l. Ulcer was Induced by administration of
Indomethacm (40 mg kg¯l p o) 30 min following pre-treatments. Results showed that Tadalafil significantly
reduced Indomethacin-mduced gastric ulcers when compared with the control group (p The ulcer area, depth and width were significantly different between the control group and the Tadalafil
10 mg kg¯l BW group. Tadalafil had ulcer-reducing effects similar to that of the reference drug, cimetidine.
Similar pattern of dose-dependent attenuation of ulcer severity was observed In the histological study. This
study provides evidence that Tadalafil possesses significant anti-gastric ulcer effects as it dose-dependently
reduced gastric ulcers induced by Indomethacin m rats.
 


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