Effects Of Aqueous Leaf Extract Of Phyllanthus Amarus On Liver Function And Blood Parameters In Male Wistar Rats.

Effects Of Aqueous Leaf Extract Of Phyllanthus Amarus On Liver Function And Blood Parameters In Male Wistar Rats.

Author by Dr. Kolawole Ajiboye

Journal/Publisher: . Journal Of Biological Innovation

Volume/Edition: 8

Language: English

Pages: 471 - 483

Abstract

Liver damage is a clinical syndrome that is characterized by the disturbances of liver function thus compromising its integrity and the capacity to meet the needs of the body. One of the most common sources of function-assault on the liver is via the ingestion of uncertified herbal products in the name of medicinal plant. Phyllanthus amarus (P. amarus) is one such herbal plant that has varied use in ethno-medicine but with minimal toxicological studies or report backing its use. This study investigated the effect of P. amarus on haematological parameters and on liver function in male Wistar rats. Thirty – six adult male rats weighing 120- 140 grams were randomly distributed into six groups of six animals each. Rats were fed with regular chow and given water ad libitum. Liver injury was induced by administration of acetaminophen (800mg/kg BW). Graded doses of P. amarus (50mg/kg and 500mg/kg BW) was administered post-liver damage induction. Silymarin (200mg/kg) was administered as the standard drug. Data was reported as mean ± SEM and analysed by One Way ANOVA, followed Newman Keul’s post hoc test. p<0>

 


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