Possible Mechanisms for the Anti-Ulcer Protective Activity of Tadalafil, a Type V Phosphodiesterase Inhibitor on Indomethacin-Induced Gastric Ulceration in Rats.

Possible Mechanisms for the Anti-Ulcer Protective Activity of Tadalafil, a Type V Phosphodiesterase Inhibitor on Indomethacin-Induced Gastric Ulceration in Rats.

Author by Dr. Kolawole Ajiboye

Journal/Publisher: European Journal Of Scientific Research.

Volume/Edition: 89

Language: English

Pages: 350 - 358

Abstract

Phosphodiesterase V inhibitors are drugs used in the treatment of erectile
dysfunction and pulmonary hypertension and reported to have the potential to mitigate
ulcer lesions in experimental models. This study examined the possible mechanisms for the
anti-ulcer protective activity of Tadalafil on indomethacin-induced gastric ulceration in
rats. We examined the effects of Tadalafil on gastric acid output, antioxidant profiles and
mucus production pattern. Male Wistar albino rats weighing between 180-220g were pre-
treated thus: Group I (Control) — saline (8ml/kg), Group II-IV- graded doses of Tadalafil
(2mg/kg, 5mg/kg and 10mg/kg body weight respectively), Group V — Reference drug.
Ulcer was induced by administration of indomethacin (40mg/kg p.o) 30min following pre-
treatments.
Tadalafil significantly reduced Indomethacin-induced gastric ulcersand total
titratable acid. All doses of Tadalafil only slightly reduced basal and histamine-stimulated
gastric acid secretion (not significant). There was no significant difference in the
antioxidant enzymes activity studied in all the groups. Tadalafil significantly enhances
mucus production in a pattern similar to Misoprostol, the reference drug. This study
provides evidence that the possible mechanisms for the significant anti-gastric ulcer effects
of Tadalafil may include, mucus secretion promoting effects, anti-secretory effects which
was not via anti-histaminic activity (1--12 receptor) and a weak antioxidant effect.
 


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