Effect of Sucrose and Date (Phoenix dactylifera) on Blood Sugar,Lipid Profile and Liver Function of Normal Wistar Rat

Effect of Sucrose and Date (Phoenix dactylifera) on Blood Sugar,Lipid Profile and Liver Function of Normal Wistar Rat

Author by Dr. Bolade Adeoye

Journal/Publisher: European Journal Of Scientific Research

Volume/Edition: 153

Language: English

Pages: 176 - 187


This research aimed at determining the effect of sucrose and date (Phoenix

dactylifera) extract in normal male wistar rats. The date extract was processed by drying,

grinding and extracting with water while table sugar was merely dissolved in water to

obtain 10 Brix respectively. Fifteen (15) male wistar rats of 9-10 weeks old were grouped

into three groups of five rats per group. Group A (control) was fed regular rat feed and

water, Group B was fed regular rat feed and sucrose solution, while Group C was given

regular rat feed and date extract. The weight and the fasting blood sugar of the animals

were taking at baseline and also weekly and every two weeks respectively. Daily food and

water intake were recorded and the experiment lasted for four weeks when the plasma

histopathology of the liver were determined. Feed intake of the control group was

significantly higher than that of the other groups while sucrose and date extract

consumption of the other two groups were significantly higher than water intake of the

control group. Groups given sucrose and date extract had significant weight gain compared

to the control group. Sucrose significantly increased the plasma concentration, glycosylated

heamoglobin, low density lipoprotein (LDL), total cholesterol and triglyceride but

decreased high density lipoprotein (HDL) of the rats. While cholesterol, HDL, LDL, and

triglyceride were not significantly different for the control and the group given date extract.

There was no significant difference in the aspartate aminotransferase (AST), alanine

aminotransferase (ALT) and liver weight. The histopathology showed that both sucrose and

date had adverse effect on the liver structure with sucrose having more pronounced effect

on the liver compared to date. Date may be a better substitute to sucrose in terms of effect

on blood sugar, lipid profile and histopathology of the liver.

glucose concentration, glycosylated heamoglobin, serum lipid profile, liver function, and

Other Co-Authors