HUMAN ADAPTATION TO PARASITISM

HUMAN ADAPTATION TO PARASITISM

Author by Mrs. Chika Okangba

Journal/Publisher: Asian Journal Of Experimental Biological Sciences

Volume/Edition: 2

Language: English

Pages: 283 - 287

Abstract

PARASITES ARE ACCOMPLISHED EVADERS OF HOSTIMMUNITY. THEIR EVASION STRATEGIES HAVE SHAPED EVERY FACET OF THE IMMUNE SYSTEM, DRIVING DIVERSITY WITHINGENE FAMILIES AND IMMUNEGENE POLYMORPHISM WITHIN POPULATIONS. THE PRESENCES OF ALLELIC FORMS FOR MANY ADAPTATIVE IMMUNE SYSTEM GENES IN PARTICULARAT T REG ASSOCIATED LOCI, SUGGESTS THAT THERE IS NO CERTAIN GENETIC OPTIMUM AND THAT IN AN ENVIRONMENT WITH DIVERSE PATHOGENS DEMANDING CONFLICTING RESPONSE PATTERNS,  THE FINE TUNNING  EFFECT OF MULTIPLE ALLELIC VARIANTS  ALLOWS  THE IMMUNE SYSTEM TO BE VARIABLY CALIBRATED ACROSS THE POPULATION . THE FIRST LINE OF DEFENSE AGAINST THE PARASITES AS WITH OTHER PATHOGENS IS THE INNATE IMM SYSTEM WHICH IS THE HARD WIRED  


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