Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

Author by Mrs. Adewoyin Osonuga

Journal/Publisher: Asian Pacific Journal Of Tropical Biomedicine

Volume/Edition: 2

Language: English

Pages: 493 - 495

Abstract

 

Objective

To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.

Methods

Sixty five albino rats with body weight of 190–220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw, respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control, and they were given water ad libitum

Results

Artemether caused significant reduction (P<0>


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