In achieving superior performance, firms around the globe encounter and manage dynamic business environmental challenges in order to maintain business superior performance over long period of time. Managers of most business organizations in today’s modern business system find it difficult to constantly achieve targeted business performance. This is due to mis-match and poor execution and implementation of strategic entrepreneurship and entrepreneurial mindset to manage uncertainties in the business environment and the invisible forces of globalization. Majority of firms in the 21st century have experienced volatility in superior performance resulting from poor understanding of strategic entrepreneurship and entrepreneurial mindset dimensions to tackle global business trends and environmental turbulence. Theoretically, the study anchored on Dynamic Capability theory and link with the conceptual model of the study. Thus, a conceptual model was developed to depict the interaction between strategic entrepreneurship and firm performance with entrepreneurial mindset as a moderator. Based on extensive literature review, the study showed that entrepreneurial mindset enhances the relationship between strategic entrepreneurship and superior firm performance. Conceptually, this paper recommended that organizational managers should employ and adopt both strategic entrepreneurship and entrepreneurial mindset measures in their business functions and direction so as to achieve superior performance.