Background: Childbirth is a critical time in the life of women during which they experience high level of pain and health care providers need to respond appropriately to the woman’s reports on labour pain. Unmet pain management often lead to psychological trauma and subsequent feto-maternal mortality therefore, this study assessed the factors influencing midwives management of labour pain at tertiary hospitals in Ekiti State. Methods: A quantitative descriptive cross-sectional design was employed through self-structured questionnaire distributed among One hundred and seventy-eight midwives, all working at the obstetric units of the tertiary hospital in Ekiti State. Result: It showed that majority 96(55.9%) of the midwives had an average knowledge, and 118(68.6%) of midwives had a positive attitude towards pain management in labour. Moreso, findings revealed a positive significant relationship between educational qualifications of midwives and labour pain management while no significant relationship was found between the labour pain management and hospitals policy. Conclusion: Lack of labour pain relief equipment, shortage of staff and hospital policies influenced midwives management of labour pain. Therefore, availability of the labour pain relief equipment should be provided with the employment of more midwives.