Cushing’s syndrome is a hormonal disorder that affects multiple systems of the body. It is caused by excessive cortisol production. Cortisol is the hormone produced by adrenal gland. Its secretions varies with circadian rhythm and its peak can be seen in the morning, however, during night it is produced in very low quantity. The pituitary gland is responsible for the secretion of adreno-corticotropic hormone, which stimulates the secretions of adrenal gland. So, if tumor develops in the pituitary gland or in adrenal gland, the secretions of cortisol ultimately increases. However, its common cause is idiopathic but it may also be caused by the excessive or prolonged intake of synthetic glucocorticoids. The disease is found 3 to 5 times more in females than in males. Menstrual irregularities, hirsutism, psychosis, plethora, fatigue and weight gain (especially centripetal obesity) are the most common clinical features. The diagnosis is normally made upon detailed history of intake of steroids and physical examination. The treatment includes both medical and surgical modalities depending upon the cause of the disease and the systems involved. This article gives an illustrative review of the disease, its causes, and diagnosis, treatment, comorbidities, complications and case reports.