Antiulcerogenic Activity of Eight Chromatographic Fractions of Ethyl Acetate Leaf Extracts of Securidaca longepedunculata fres. (Polygalaceae) and Luffa cylindrica (L.) Roem. (Cucurbitaceae)

Antiulcerogenic Activity of Eight Chromatographic Fractions of Ethyl Acetate Leaf Extracts of Securidaca longepedunculata fres. (Polygalaceae) and Luffa cylindrica (L.) Roem. (Cucurbitaceae)

Author by Dr. Abolanle Kayode

Journal/Publisher: Oriental Journal Of Chemistry

Volume/Edition: 36

Language: English

Pages: 100 - 105

Abstract

Securidaca longepedunculata (SL) and Luffa cylindrica (LC) leaf extracts have been shown to exhibit significant antiulcer effect on ethanol-induced gastric lesions. This study examined the antiulcerogenic effect of chromatographic fractions of ethyl acetate extracts of the selected plants. The ethyl acetate extracts of (SL) and (LC) were fractionated using Vacuum Liquid Chromatography (VLC). Antiulcer screening was carried out on the eight chromatographic fractions obtained. The fractionation afforded four fractions (A, B, C and D) each for Securidaca longepedunculata and Luffa cylindrica. Twenty groups of 5 rats each were treated with 50 and 100 mg/kg b.w of LCA1-LCD2 and SLA1-SLD2, respectively. Fraction B of LC (LCB2, 100 mg/kg b.w) gave the highest percentage of ulcer inhibition (94.9%) while fraction D of SL (SLD2, 100 mg/kg b.w) showed the highest percentage protection (92.3%), against ethanol-induced gastric ulcer. Chromatographic fractions of the ethyl acetate extracts may also possess antiulcerogenic property


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