Malaria infection is a public health problem of global concerns. Malaria is an endemic disease in major areas of Africa and some part of America and Asia. Typical symptoms of malaria include headaches, fever, vomiting, rigors, chills and tiredness while severe malaria could lead to seizures, coma, severe anaemia, respiratory distress, convulsions, hypoglycemia, yellow skin or death. Effective management of malaria begins with an accurate diagnosis of the disease. Identification of malaria parasites or antigens are used for malaria diagnosis. An understanding of the plasmodium’s metabolism could be explored to develop new therapeutic strategies. However, there were observable resistances noted in P. falciparum, which, continually threatens their efficacy and has necessitated the need new antimalarial combinations and the discovery, design and development of new drugs.