Therapeutic Effect of Yo-Yo Bitters and Evans Healthy Bitters against Acetaminophen-Induced Hepatotoxicity in Mice

Therapeutic Effect of Yo-Yo Bitters and Evans Healthy Bitters against Acetaminophen-Induced Hepatotoxicity in Mice

Author by Dr. Abolanle Kayode

Journal/Publisher: International Journal Of Innovative Science And Research Technology

Volume/Edition: 4

Language: English

Pages: 590 - 594

Abstract

Yo-Yo bitters and Evans healthy bitters are brands of polyherbal preparations/mixtures widely consumed in Nigeria. However, there is scarcity of scientific data on the acclaimed medicinal or therapeutic benefits of these bitters. The effects of these bitters on acetaminophen - induced hepatotoxicity in mice was examined using liver function data obtained from the liver of mice. Thirty Wistar mice divided into 6 groups of 5 mice each were used. Group 1 was injected with 0.15 mL of acetaminophen (AAP) and group 4 (control) was injected with 0.03 mL of normal saline. Group 2 and group 3 were injected with 0.3 mL of Yo-Yo bitters and 0.3 mL of Evans Healthy bitters, respectively. Group 5 and 6 were injected with 0.15 mL of AAP and then treated with 0.3 mL of Evans Healthy bitters and 0.3 mL of Yo-Yo bitters, respectively. The mice were sacrificed four hours after the last treatment and the liver collected for Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and alkaline phosphatase (ALP) bioassays. Treatment with acetaminophen alone caused significant (p<0>


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