Nutritional anaemia is one of Nigeria's major public health problem among pregnant women. In this locality,
no. large scale study has been done to assess bone marrow activity in groups of pregnant women using Reticulocyte assessment.
This result will serve as indirect evaluation and elaboration of erythroid marrow output in the pregnant women.
Aim: To assess bone marrow activity in groups of pregnant women using Reticulocyte assessment as an indirect evaluation.
Method: ISO women covering the three trimesters of pregnancy were recruited into the study, prospectively.
lOt multiparous and 49 primiparous pregnant women, consisting of 33 in the first trimester, 74 in the second trimester and
43 in the third trimester wore investigated. Red blood cell count, Reticulocyte count and assessment were conducted by standard
Results: The patients in the third trimester had statistically significant (P
the first and second trimesters. The primiparous pregnant women had statistically significant (P
than the multiparous pregnant women, Absolute reticulocyte count results were SO.O±IS.2, 60.0±18.4, 34.0±12.8 and 48.0±12.0
for first, second and third trimesters and combined group, respectively. Reticulocyte index was l.S±O.6, I.9±O.8, O.8±O.6 for
first, second and third trimesters, respectively and I.S±O.5 for combined group. Reticulocyte production index was O.9±O.2,
i.I±0.4, 0.7±O.S and O.7±0.4 for first, second and third trimesters and combined group, respectively.
Conclusion. In this study, bone marrow activity as assessed by reticulocyte studies is on the lower side of the normal
range, more so in the third trimester of pregnancy. Severe anaemia during pregnancy therefore remains endemic despite intervention
measures such as the distribution of iron and folate tablets. One of the problems yet un investigated is the bone marrow turnover
as affected by some other nutritional differences as well as malaria; heavy loads of helminths, and other inflammatory or infectious
diseases. A successful strategy to combat anaemia, therefore, should address all the casual factors after their elucidati