Asymptomatic falciparum malaria and the prevalence of Pfcrt K76T mutation: Challenges for malaria control in Nigeria

Asymptomatic falciparum malaria and the prevalence of Pfcrt K76T mutation: Challenges for malaria control in Nigeria

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Journal/Publisher: International Journal Of Infectious Diseases

Volume/Edition: 21

Language: English

Pages: 161 - 161

Abstract

Malaria remains a public health challenge especially in sub-Sahara Africa where asymptomatic malaria in adults and pregnant women is not uncommon. In the present study, the prevalence of asymptomatic malaria was investigated in a cohort of Nigerian children (almajiris) and the genetic polymorphisms of CQ resistance biomarkers were assessed. Methods & Materials: Four hundred and forty (440) apparently healthy almajiris aged 3-12 years were randomly enrolled in Maiduguri, Nigeria between July and December 2010. Falciparummalariawasdiagnosedbymicroscopyandnestedpolymerase chainreaction(PCR).UsingPCR,thegeneticpolymorphismsofPlasmodium falciparum chloroquine transporter codon 76 (Pfcrt K76T) and Plasmodium falciparum multidrug resistant locus 1 codon 86 (Pfmdr1N86Y)weredeterminedinthePlasmodiumfalciparumisolatedfromthesubjects.TheethicalapprovalwasgrantedbyEthics Committee, Ministry of Health, Borno State. Results: The mean age of the subjects was 8.3+4.5years; with subjects<5years df=1; p=0.00001).>


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