In silico Sequence Analysis, Homology Modeling and Function Annotation of Farnesyl Diphosphate Synthase (FDS) of Azadirachta indica

In silico Sequence Analysis, Homology Modeling and Function Annotation of Farnesyl Diphosphate Synthase (FDS) of Azadirachta indica

Author by Dr. John Afees Olanrewaju

Journal/Publisher: Journal Of Applied Bioinformatics &computational Biology

Volume/Edition: 7

Language: English

Pages: 1 - 7

Abstract

Azadirachta indica is commonly referred to as Neem and is a member of the mahogany family, Meliaceae. Azadirachta indica has enormous therapeutic benefits and can show antibacterial activity, antiviral activity, anti-inflammatory activity, antioxidant effect and anticarcinogenic activity. Hence, it is recognized as a tree for solving global health problems. In the present study, subcellular localization prediction reveals that FDS of Azadirachta indica is a cytoplasmic protein. We predicted the 3D structure of the protein using homology modeling as 3D structure prediction methodology. The 3D structure of FDS was determined using SwissModel. Quality assessment of the model indicated that the model is reliable. Furthermore, it was discovered that FDS is involved in biological processes; metabolic process, cellular process, cellular metabolic process, primary metabolic process and the biochemical function of the protein is involved in transferase activity and metal ion binding


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