Relationship of oxidative stress with type 2 diabetes and hypertension

Relationship of oxidative stress with type 2 diabetes and hypertension

Author by Dr. Stanley I. R. Okoduwa

Journal/Publisher: Journal Of Diabetology

Volume/Edition: 2013

Language: English

Pages: 1 - 13

Abstract

Hypertension and diabetes commonly occur together. The aim of this study was to investigate the roleof oxidative stress in the link among Northern Nigerians.The study involved 200 subjects (aged 20 to 79 years) divided into four groups of 50 subjects each, viz.: Non Diabetic Normotensive Persons (NDNP) as controls, while Diabetic Normotensive Patients (DNP), Non Diabetic Hypertensive Patients (NDHP) and Diabetic Hypertensive Patients (DHP) as cases. Biomarkers of oxidative stress were correlated with some trace mineral elements in serum samples collected from all the subjects.A significant (p < 0>negative correlation was observed between the following: CAT/MDA and Fe2+/MDA in the 3 case groups; SOD/MDA, GSH/MDA in both DNP and DHP groups; Vitamin C/MDA, Se2+/MDA and Zn2+/MDA in both NDHP and DHP groups. The negative correlation of Vitamin E with MDAwas found to be significant (p < 0>trace mineral elements obtained in this study is implicated in the changes in antioxidant defense system which resulted in the pathophysiologic mechanisms underlying the complication of type 2 diabetes and associated hypertension


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