The Usefulness of Staged Gamma Knife Radiosurgery (GKRS) in the Management of Large Voluminous Benign Brain Tumours

The Usefulness of Staged Gamma Knife Radiosurgery (GKRS) in the Management of Large Voluminous Benign Brain Tumours

Author by Dr. Eghosa Morgan

Journal/Publisher: Journal Of Clinical And Applied Neurosciences

Volume/Edition: 2

Language: English

Pages: 63 - 70

Abstract

ABSTRACT Background: Gamma Knife Radiosurgery (GKRS) is a form of surgical ablation, probably, by targeted cell death, without the risks of open surgery. Its application in the treatment of large voluminous benign tumours could result in low efficiency in tumour cell ablation and high risk of damage to contiguous structures. Thus, a staging of the procedure has been advocated.  Objective: The aim of this study is to buttress the usefulness of staged gamma knife radiosurgery for benign brain tumours. Methodology: Between June 2008 and November 2013 staged gamma knife radiosurgery (GKRS) was performed on six patients, aged 1753years, with large voluminous benign brain tumours. All the patients had, at least, one surgical intervention aimed at either diverting cerebrospinal fluid by shunting and/or tumour decompression via surgical intervention. Patients had undergone surgery at least once. The prescription dose of radiation was 9-12Gy (Gray). Follow-up period ranged 2-5years, and except for one, all the patients improved clinically.  Results: Tumour control was achieved in 5 out of 6 patients (83%), with one being stable in terms of tumour volume. Of the 5, two had slight tumour reduction and none of them had progression of tumour volume. Conclusion: The GKRS has remarkable benefits in the control of benign brain tumour progression, and has attendant low concomitant morbidity. Staged GKRS procedure represents a safe treatment option for large benign tumours in critical locations (deep seated location with close proximity to neural and vascular structures) following an incomplete surgical resection or as primary treatment for patients with poor medical condition


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