This study investigated the factors influencing the utilization of infection prevention and control strategies (IPCM) among nurses in some selected state hospitals in Lagos State. It adopts a descriptive cross-sectional research design using multistage sampling technique to recruit 158 nurses. Selfstructured questionnaire with reliability index of 0.79 was used for data collection. Obtained data was analyzed using descriptive and inferential statistics. Findings revealed that 84.8% of respondents used IPCM while 15.2% didn’t use this. The factors reported by respondents to influence utilization of IPCM include; attitude of nurses (p=0.001), unavailability of personal protective equipment (p=0.009), poor knowledge about IPCM (p=0.034), prompt supervision by hospital’s infection control committee (p= 0.022), accessibility of materials for infection prevention and control (p= 0.042), frequent trainings on infection prevention and control procedures (p= 0.036) while year of practice ( p=0.645) and Qualification (p= 1.000) does not have influence on utilization of IPCM .Majority in this study use IPCM but few do not make use of it which can cause fatal consequences. Hospitals should set up infection control committee to train and enforce safe practices among nurses and hospital management should also ensure availability accessibility of personal protective equipment to health care workers for safe practice.