Gender-Related Alterations in Free Fatty Acids and Enhanced Oxidative Stress in Hypertension Co-Morbidly Occurring with Type-2-Diabetes Mellitus Subjects

Author by Dr. Gogonte Amah

Journal/Publisher: Proceedings Of The Maiden Bioscience Annual Conference, Federal University Of Agriculture, Abeokuta

Volume/Edition: 1

Language: English

Pages: 46 - 52

Abstract

Increase in plasma free fatty acids (FFAs) concentrations may cause cellular damage via the induction of
oxidative stress. The aim of this present study was to investigate FFAs and oxidative stress in hypertension comorbidly occurring with type-2-diabetes mellitus (T2DM). Age and sex matched control subjects (n=150) and
patients (n=470) [hypertensive nondiabetics (HND, n=179), normotensive diabetics (ND, n=132), hypertensive
diabetics (HD, n=159)] presenting at the Medical Out-Patient Clinic of the State Hospital, Abeokuta, Nigeria
were recruited. Fasting plasma glucose, creatinine, urea, FFAs, thiobarbituric acid reactive substances (TBARS)
were determined spectrophotometrically. The presence of either or both diseases resulted in significant increase
(p<0> and lipoproteins) for both male and female patients when compared with their control counterparts. The increase
in FFAs was more marked in comorbidity female when compared with other female patients. There was significant
(p<0> significantly (p<0> biochemical variations in hypertension co-morbidly occurring with T2DM characterised by gender-related
alterations in FFAs and enhanced oxidative stress. Plasma FFAs might be a good biomarker predicting the
occurrence and development of hypertension and/or T2DM.
 

Other Co-Authors