Neuroprotective Effects of Garcinia kola ethanol Seed Extract on Haloperidol-Induced Catalepsy in Mice
Abstract
Antipsychotic drugs are known to cause irreversible neurodegeneration through oxidative mechanisms. Garcinia kola is known for its capacity to scavenge free radicals. This study elucidated the neuroprotective properties of ethanol extract of Garcinia kola (EGK) nuts on haloperidol (HP)-induced catalepsy. Forty male Swiss albino mice (Mus musculus) (2-3 weeks old, 19-25g) were grouped into 8 (n=5) as follows: Groups I (2 mL/kg propylene glycol), II (haloperidol{HP}), III (200 mg/kg + HP) and IV (400 mg/kg EGK + HP), V(HP + 200 mg/kg EGK), VI (HP + 400 mg/kg EGK), VII (HP + 200 mg/kg EGK) and VIII (HP + 400 mg/kg EGK). Haloperidol was administered intraperitoneally at a dose of (1 mg/kg). Neurobehavioural assessments for locomotor activity, memory, anxiety and catalepsy scoring involved the use of elevated plus maze and the open field apparatus on the 1st, 8th, and 15th day of the study. Brain malondialdehyde (MDA) and glutathione (GSH) concentrations were assayed using colorimetric method. Haloperidol significantly reduced (p<0>
Mr. Opeyemi Debola Adetunji