ETHANOL AND BENZENE INDUCED TOXICITY IN WISTAR RATS: AMELIORATIVE EFFECTS OF EXTRA-VIRGIN OLIVE OIL ON HAEMATOLOGICAL INDICES AND SPLEEN DAMAGE

ETHANOL AND BENZENE INDUCED TOXICITY IN WISTAR RATS: AMELIORATIVE EFFECTS OF EXTRA-VIRGIN OLIVE OIL ON HAEMATOLOGICAL INDICES AND SPLEEN DAMAGE

Author by Mr. Opeyemi Debola Adetunji

Journal/Publisher: European Journal Of Pharmaceutical And Medical Research

Volume/Edition: 9

Language: English

Pages: 523 - 531

Abstract

Background: The metabolic intermediates of benzene and ethanol are relatively poisonous to humans. Extra virgin olive oil (EVOO) is considered a natural source of bioactive compounds with beneficial effects on multiple organs. There is a dearth of empirical information on its protective roles in relieving symptoms associated with ethanol and/or benzene intoxication. Objective: This study was conducted to investigate the effects of extra virgin olive oil benzene and/or ethanol-induced haematological and splenic tissue aberrations in rats. Methodology: Forty-eight female Wistar rats (110kg-170kg) were randomly divided into 8 groups (n=6); Negative Control, EVOO= Extra Virgin Olive Oil, ETH= Ethanol, BEN= Benzene, ETH+BEN= Ethanol + Benzene, ETH+EVOO= Ethanol+ Extra Virgin Olive Oil, BEN+EVOO= Benzene+ Extra Virgin Olive Oil, ETH+BEN+EVOO= Ethanol+Benzene+ Extra Virgin Olive Oil. Animals were sacrificed and blood samples were collected for food blood count (FBC) analysis. Data were analyzed with a graph pad prism (version 5.03). p<0>


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