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Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic

Authors: EHICHIOYA David

Publication Type: Journal article

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Abstract

Background: Momordica Charantia (MC), widely cultivated around the world for its medicinal and nutritional purposes, has been reported to have hypoglycemic properties. Aim: This study was conducted to determine the effect of MC leaf extract and anti-diabetic drug on oral glucose tolerance test (OGTT) in female Sprague Dawley. Methods: Fifty apparently healthy female rats selected into 5 groups of 5 rats each were used for this study. The study was done in 2 stages: Stage 1: Simultaneous administration of glucose, MC and/or perglim-2 (Groups: A1-Control; B1-Glucose; C1- Glucose + MC; D1-Glucose + Perglim m-2 and E1- Glucose, MC and Perglim m-2). Stage 2: Administration of glucose 45minutes after MC and/or perglim m-2 had been administered (Groups: A2-Control; B2- Glucose; C2-Glucose + MC, D2-Glucose + Perglim m-2 and E2-Glucose, MC and Perglim m-2). In experimental rats that fasted for 18hours, fasting blood glucose was determined before the commencement of the study. After oral administration of glucose, MC and/or perglim m-2, blood glucose level was monitored in the rats at time intervals of 0, 15, 30, 45, 60, 75, 90, 105 and 120minutes using Accu-chek glucometer. Result: The result showed that MC and perglim m-2 demonstrated significant decrease (P>0.05) in the blood glucose level of administered rats when compared with the control group in both stages. Conclusion: Aqueous extract of MC leaves was observed to exhibit the potential to correct impaired glucose tolerance although not for a long duration of time.

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EHICHIOYA,D. . (0000). Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic, 0 (), 0-0.

EHICHIOYA,D. . "Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic" 0, no (), (0000): 0-0.

EHICHIOYA,D. and . (0000). Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic, 0 (), pp0-0.

EHICHIOYAD, . Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic. 0000, 0 ():0-0.

EHICHIOYA,David , . "Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic", 0 . (0000) : 0-0.

E.David , "Oral glucose tolerance test in female Sprague Dawley rats administered with leaf extract of Momordic" vol.0, no., pp. 0-0, 0000.

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