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A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue

Authors: OGUNSOLA Oluseyi

Publication Type: Journal article

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Abstract

This study compares the pathophysiology of normal and growth retarded human placental tissues. Female patients were recruited fromthe Antenatal Clinic of Dolu Specialist Hospital,Mafoluku, Oshodi, Lagos, between 2008 and 2012. A total of 48 normal term placentas and 15 placentas of known IUGR cases were used for this study. IUGR cases were confirmed on the basis of ultrasound follow-up and diagnosis.Normal termplacentas were collected at the point of delivery by a consultant gynaecologist, the cords were clamped, andmembraneswere then carefully trimmed afterwhich each placenta wasweighed.About 1 cmthickness of both normal and growth retarded placenta tissues was cut, processed for hematoxylin and eosin stain, while tissues for enzyme (ALP) assay were homogenized in cold 0.5M sucrose solution. Comparative analysis of the data was done using ANOVA; ð‘ƒ < 0.05 was taken as significant. The photomicrographs were observed/studied under light microscope, using the X150 and X600 magnifications. It was revealed therein that placental tissues are homogenous (regionally), compromised ofmaternal spiral arterioles and deregulated villous vasculogenesis, and that there is a significant difference in the level of alkaline phosphatase enzyme.We therefore concluded that there is a distinct difference between the normal and growth retarded human placenta tissue.

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OGUNSOLA,O. . (0000). A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue, 0 (), 0-0.

OGUNSOLA,O. . "A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue" 0, no (), (0000): 0-0.

OGUNSOLA,O. and . (0000). A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue, 0 (), pp0-0.

OGUNSOLAO, . A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue. 0000, 0 ():0-0.

OGUNSOLA,Oluseyi , . "A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue", 0 . (0000) : 0-0.

O.Oluseyi , "A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue" vol.0, no., pp. 0-0, 0000.

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