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INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES

Authors: OGUNSOLA Oluseyi

Publication Type: Journal article

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Abstract

Objective: To establish a reference range of insulin growth factor1 (IGF-I) in normal fetuses and to assess whether intrauterine growth retardation is associated with increased or decreased IGF- I levels. Method: Retrospective analysis of blood samples collected from n= 45 fetuses who underwent blood sampling at 18 - 38 weeks gestation was performed: 25 fetuses, who were considered controls, were appropriately grown for gestational age and were found unaffected by the condition for which they were tested, the remaining (n=20) underwent fetal blood sampling to assess fetal karyotype following ultrasonic diagnosis of intra-uterine growth. Insulin growth factor1 (IGF-I) levels was measured using ELISA technique (Diagnostic system Laboratories, Webster, Texas, USA). Intra- coefficient of variation of the test ranged from 4.1 to 6.1%. Data was analysed using Studentâ€™s t test. Result: In the control group, serum level of IGF -1 increased linearly with gestational age, while in growth-retarded fetuses, IGF- 1 levels were not significantly different. Conclusion: Our study confirmed previous findings that IGF-1 level paralleled increase in fetal growth with advancing gestational age. The absence of an increase in IGF-1 level in growth-retarded fetuses may indicate a terminal process in fetal adaptation to placental failure.

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OGUNSOLA,O. . (0000). INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES, 0 (), 0-0.

OGUNSOLA,O. . "INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES" 0, no (), (0000): 0-0.

OGUNSOLA,O. and . (0000). INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES, 0 (), pp0-0.

OGUNSOLAO, . INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES. 0000, 0 ():0-0.

OGUNSOLA,Oluseyi , . "INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES", 0 . (0000) : 0-0.

O.Oluseyi , "INSULIN GROWTH FACTOR 1 IN NORMAL AND GROWTH- RETARDED FETUSES" vol.0, no., pp. 0-0, 0000.

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