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Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection

Authors: Adediji Isaac , ENITAN Samson , OFEM Oluchi , & Faloye

Publication Type: Journal article

Journal: International Journal Of Herbal Medicine

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Abstract

The curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora (MLEPC) was assessed in rats challenged with experimental Pseudomonas aeruginosa urinary tract infection. Rats with culture-proven Pseudomonas aeruginosa UTI were treated with different doses of MLEPC (250, 500, 750 and 1000 mg/Kg/bid), as well as equal volume (50:50) of 500 mg/Kg/bid MLEPC and 500 mg/Kg/bid Ciprofloxacin suspension combined, administered orally twice daily for 7days. The animals were sacrificed on day 2, 4, 8 and 16 to determine bacterial burden in urine and urinary organs homogenates, as well as urine leucocytes count using standard methods. Urinary levels of acid phosphatase (ACP), alkaline phosphatase (ALP), Creatinine and Urea were also evaluated spectrophotometrically using kits to determine the nephrotoxic potential of the extract. The treatment outcome of our experimental P. aeruginosa UTI in animal model revealed that the MLEPC produce a progressive significant reduction (P<0>

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Adediji,I. ENITAN,S. OFEM,O. ,F. . (0000). Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection, 4 (), 49-49.

Adediji,I. ENITAN,S. OFEM,O. ,F. . "Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection" 4, no (), (0000): 49-49.

Adediji,I. and ENITAN,S. and OFEM,O. and ,F. and . (0000). Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection, 4 (), pp49-49.

AdedijiI, ENITANS, OFEMO, F, . Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection. 0000, 4 ():49-49.

Adediji,Isaac , ENITAN,Samson , OFEM,Oluchi , and ,Faloye . "Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection", 4 . (0000) : 49-49.

A.Isaac E.Samson O.Oluchi & .Faloye , "Curative and nephrotoxic potential of methanolic leaf extract of Plukenetia conophora Mull arg. in rats challenged with Pseudomonas aeruginosa urinary tract infection" vol.4, no., pp. 49-49, 0000.

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