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Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria

Publication Type: Journal article

Journal: 118

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Abstract

AIM: To determine the perinatal transmission risk of hepatitis B virus (HBV) and the maternal characteristics influencing it.
METHOD: During routine antenatal screening, women who tested positive for hepatitis B surface antigen (HBsAg) were
identified and followed through pregnancy. Maternal and cord blood samples were obtained at delivery. The sera of each motherbaby
pair were analyzed for HBsAg, HBeAg, HBeAb, HBsAb and HBcAb using an immunochromatographic 5-in-1 panel
kit. Quantitative HBV-DNA was assessed using polymerase chain reaction technique. Intrauterine infection was defined when
neonatal blood test positive for HBsAg positivity and/or HBV-DNA. Confidence level was set at 95% (p < 0> RESULTS: Of the 716 pregnant women screened 73 (10.2%) were HBsAg-positive. Fifty of these HBsAg-positive women
completed the study. Intrauterine infections were detected in 36 (72%) newborns; of them only twelve (24%) had positive
HBsAg whereas all of them (n = 36) neonates had detectable HBV-DNA (>100 copies/ml). High maternal HBV-DNA titre was
associated with increased neonatal HBV-DNA titre (p = 0.001). Parity, maternal age, and mode of delivery showed no association
with perinatal transmission.
CONCLUSION: The risk of perinatal HBV transmission in this study was high. Perinatal transmission was associated with
high maternal viremia. Appropriate prophylaxis for HBsAg-positive mothers and their newborns is advocated.

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OLALEYE,A. Olufemi,K. . (0000). Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria, 6 (), 231-231.

OLALEYE,A. Olufemi,K. . "Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria" 6, no (), (0000): 231-231.

OLALEYE,A. and Olufemi,K. and . (0000). Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria, 6 (), pp231-231.

OLALEYEA, OlufemiK, . Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria. 0000, 6 ():231-231.

OLALEYE,Atinuke , and Olufemi,Kuti . "Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria", 6 . (0000) : 231-231.

O.Atinuke & O.Kuti , "Perinatal transmission of hepatitis B virus infection in Ile-Ife, South Western, Nigeria" vol.6, no., pp. 231-231, 0000.

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