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Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria.

Authors: Umaru Ladi, Abdu-aguye , Zezi , UYAIABASI Gabriel , Danjuma Mohammed Nuhu

Publication Type: Journal article

Journal: Journal Of Pharmacology And Tropical Therapeutics

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Abstract

The artemisinin combination therapies (ACT) are the drug of choice for the treatment of uncomplicated malaria in regions endemic for the disease. WHO encourages all countries using the ACTs drugs to carry out efficacy study once every 24 months. This study assessed the therapeutic efficacy and safety of dihydroartemisinin/piperaquine (DP) in the treatment of uncomplicated P. falciparum malaria in patients attending General Hospital Makarfi, Kaduna State – Nigeria. Patients with symptoms of malaria attending the hospital were screened for the disease and those who satisfied the study protocol were subsequently enrolled and divided into 3 age groups: under 5, 5 -14, and 15 years & above. All patients were treated with standard doses of DP and followed – up over 42 days. DP demonstrated fast fever and parasite clearance properties in all treatment groups. PCR – uncorrected result showed 100% and 94.5?ficacy after 28 and 42 days of follow-up respectively. The drug was safe with very few adverse effects and was well tolerated. DP is an effective, safe and convenient ACT for the treatment of uncomplicated P. falciparum malaria and could serve as a suitable alternative to artemether/lumefantrine.

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Umaru,M.L Abdu-aguye,I. Zezi,U. UYAIABASI,G. Danjuma,M.N . (0000). Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria., 1 (), 38-38.

Umaru,M.L Abdu-aguye,I. Zezi,U. UYAIABASI,G. Danjuma,M.N . "Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria." 1, no (), (0000): 38-38.

Umaru,M.L and Abdu-aguye,I. and Zezi,U. and UYAIABASI,G. and Danjuma,M.N and . (0000). Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria., 1 (), pp38-38.

UmaruML, Abdu-aguyeI, ZeziU, UYAIABASIG, DanjumaMN, . Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria.. 0000, 1 ():38-38.

Umaru,Millicent Ladi, Abdu-aguye,Ibrahim , Zezi,Umar , UYAIABASI,Gabriel , and Danjuma,Mohammed Nuhu . "Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria.", 1 . (0000) : 38-38.

U.Millicent Ladi A.Ibrahim Z.Umar U.Gabriel & D.Mohammed Nuhu , "Therapeutic efficacy and safety of Dihydroartemisinin/Piperaquine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Makarfi, Kaduna state, Nigeria." vol.1, no., pp. 38-38, 0000.

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