Babcock University Research Portal

Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats

Authors: ENITAN Samson

Publication Type: Journal article

Journal: International Journal Of Herbal Medicine

ISSN Number:

Downloads

Views

Abstract

The hepato- and nehro-protective potentials of aqueous root extract of Gongronema latifolium against
paracetamol-induced hepatotoxicity and Chloroquine induced nehrotoxicity in adult albino rats, were
studied. Thirty six (36) albino rats weighing between 200±34g were used for this study. They were
randomly divided into nine groups (1-9), where group 1 served as the zero control (baseline).
Hepatotoxicity was induced in groups 2, 6, and 7 via oral administration of paracetamol 600mg/kg body
weight, while group 3, 8 and 9 were induced with nephrotoxicity via oral administration of chloroquine
69mg/kg body weight. These were treated for 14 days, except for group 2 and 3 which served as the
hepatotoxic and nephrotoxic controls, respectively. Group 4 and 5 which served as extract controls were
given100mg/kg and 200mg/kg of Gongronema latifolium root extract, respectively. Serum liver enzymes
(Alanine aminotransferase, Aspartate aminotransferase and Alkaline phosphatase), urea and creatinine
levels were evaluated spectrophotometrically in accordance with the methods provided by the diagnostic
kits (Teco Diagnostic, Anaheim, USA). The outcome of this study showed that the mean±SEM serum
ALAT, ASAT and ALP levels of the Paracetamol + Extract groups, as well as the mean±SEM serum urea
and creatinine levels of the Chloroquine + Extract groups were significantly decreased (P<0> of the hepatotoxic and nephrotoxic control, respectively, in a dose-dependent manner. This study
indicates that aqueous root extract of Gongronema latifolium exerted significant protection against
Paracetamol induced hepatotoxcity and chloroquine induced nephrotoxicity.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

ENITAN,S. . (0000). Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats, 5 (), 115-115.

ENITAN,S. . "Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats" 5, no (), (0000): 115-115.

ENITAN,S. and . (0000). Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats, 5 (), pp115-115.

ENITANS, . Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats. 0000, 5 ():115-115.

ENITAN,Samson , . "Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats", 5 . (0000) : 115-115.

E.Samson , "Protective effect of aqueous root extract of Gongronema latifolium against paracetamol induced hepatotoxicity and chloroquine induced nephrotoxicity in rats" vol.5, no., pp. 115-115, 0000.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION