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Pattern of triple negative epithelial ovarian cancer in indigenous African women

Authors: AJANI Mustapha , Ayodeji Salami, Olutosin Awolude, Abideen Olayiwola Oluwasola

Publication Type: Journal article

Journal: F1000research

ISSN Number:

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Abstract

Background: Triple negative epithelial ovarian cancer (TNEOC) refers to
ovarian carcinomas that do not express estrogen receptor (ER), progesterone
receptor (PR) and human epidermal growth factor receptor- type 2
(HER-2/neu). The aim of this study is to determine the pattern of triple negative
epithelial ovarian cancer in indigenous African women.

Methods: We performed a retrospective review of ER, PR and HER-2/neu
expression in 90 Nigerian patients with histologically diagnosed epithelial
ovarian cancer. Lack of expression of ER, PR and HER2/neu antigens was
used to determine carcinomas that are among the TNEOC. We also compared
the clinicopathological parameters (age, International Federation of
Gynaecology and Obstetrics (FIGO) stage, grade and histological subtype) in
patients with TNEOC and non- TNEOC.

Results: Thirty-eight (42.2%) of the 90 tumours diagnosed as EOC were
negative for ER, PR and HER2/neu expression. There was no significant
association between TNEOC with other parameters such as age, FIGO stage
and histological grade. Sixteen (66.7%) of the 24 mucinous carcinomas were
triple negative, while only 21 (33.3%) of the 63 serous carcinomas were
triple-negative and one (50%) of the two endometrioid carcinomas was triple
negative. There was a significant association between triple-negative tumours
and histological subtypes of EOC (p = 0.034).

Conclusions: A subtype of epithelial ovarian cancer that is negative for ER, PR
and HER-2/neu has been discovered in indigenous African women. TNEOC
expression is high and is comparable to the triple negative breast cancer
subtype seen in people of African ancestry. Future study of TNEOC in a large
sample size should be considered.

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AJANI,M. Ayodeji,A.S Olutosin,A.A Abideen,O.O . (0000). Pattern of triple negative epithelial ovarian cancer in indigenous African women, 5 (), 1-1.

AJANI,M. Ayodeji,A.S Olutosin,A.A Abideen,O.O . "Pattern of triple negative epithelial ovarian cancer in indigenous African women" 5, no (), (0000): 1-1.

AJANI,M. and Ayodeji,A.S and Olutosin,A.A and Abideen,O.O and . (0000). Pattern of triple negative epithelial ovarian cancer in indigenous African women, 5 (), pp1-1.

AJANIM, AyodejiAS, OlutosinAA, AbideenOO, . Pattern of triple negative epithelial ovarian cancer in indigenous African women. 0000, 5 ():1-1.

AJANI,Mustapha , Ayodeji,Akeem Salami, Olutosin,Alaba Awolude, and Abideen,Olayiwola Oluwasola . "Pattern of triple negative epithelial ovarian cancer in indigenous African women", 5 . (0000) : 1-1.

A.Mustapha A.Akeem Salami O.Alaba Awolude & A.Olayiwola Oluwasola , "Pattern of triple negative epithelial ovarian cancer in indigenous African women" vol.5, no., pp. 1-1, 0000.

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