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Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species

Authors: ADEOYE-ISIJOLA Morenike , & OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: Life Science Journal

ISSN Number:

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Abstract

Abstract: The development of multiple antibiotic resistances in microbial communities is gaining momentum as
many chemotherapeutic agents are obsolete and ineffective to curtail the menace of pathogenic microbes.
Consequently, efforts are now geared towards the development of new potent antibiotics while we explore the
potentials of drug combinations to improve antibiotic effectiveness. This study investigated the effect of combining
benzylpenicillin, streptomycin and amoxicillin against bacterial isolates by agar dilution and agar diffusion methods.
The results showed that streptomycin was the most effective against the bacterial isolates having MICs ranging
between 2 ?g/ml and 200 ?g/ml while amoxicillin inhibited the bacterial isolates at MICs ranging between 20 ?g/ml
and 400 ?g/ml and benzylpenicillin inhibited the isolates at concentrations ranging between 20 ?g/ml and 200
?g/ml. Amoxicillin combined with benzylpenicillin and amoxicillin combined with streptomycin were not
synergistic against any isolate. Amoxicillin combined with benzylpenicillin resulted in additive interaction against
K. pneumoniae ATCC 1538, S. aureus ATCC 29213 and E. coli ATCC 23922 but antagonistic against E. coli ATCC
25922 and P. aeruginosa ATCC 27853. Amoxicillin combined with streptomycin resulted in additive interaction
against E. coli ATCC 23922, K. pneumoniae ATCC 1538 and E. coli ATCC 25922 but antagonistic against S.
aureus ATCC 29213 and P. aeruginosa ATCC 27853. Benzylpenicillin combined with streptomycin resulted in
synergistic interaction against S. aureus ATCC 29213, E. coli ATCC 23922 and P. aeruginosa ATCC 27853,
additive interaction against S. aureus ATCC 29213 and antagonistic interaction against E. coli ATCC 25922. This
study showed that synergistic drug pairs can effectively eradicate bacteria while antagonistic drug pairs would
reverse the trend especially when targeting bacterial strains with a combination of drugs of unknown interactions.

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ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. . (0000). Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species, 13 (), 37-37.

ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. . "Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species" 13, no (), (0000): 37-37.

ADEOYE-ISIJOLA,M. and OLAJUYIGBE,O. and . (0000). Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species, 13 (), pp37-37.

ADEOYE-ISIJOLAM, OLAJUYIGBEO, . Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species. 0000, 13 ():37-37.

ADEOYE-ISIJOLA,Morenike , and OLAJUYIGBE,Olufunmiso . "Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species", 13 . (0000) : 37-37.

A.Morenike & O.Olufunmiso , "Synergistic potentials of benzylpenicillin, amoxicillin and streptomycin antibiotics against selected bacterial species" vol.13, no., pp. 37-37, 0000.

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