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HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.

Authors: Aleshinloye Abimbola Ololade

Publication Type: Journal article

Journal: International Journal Of Advanced Research

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Abstract

This study evaluated the effects of a polyherbal formula on the plasma
lipid profile and blood glucose in Streptozotocin-induced diabetic rats.
A single dose of Streptozotocin (STZ), (60 mg/kg body weight) in
sodium citrate buffer at pH 4.5 was used to induce diabetes
intraperitoneally in 20 adult Albino Wistar Strain Rats. 25 rats were put
into 5 groups: Normal, Standard, Control, Test I and Test II
respectively and were sacrificed after 7days of treatment. The weight
and glucose baseline were taken prior to: (1) STZ administration (2)
after a week of inducing diabetes (3) after the first, third and fifth day
of treatment and (4) at sacrificial time. The body weight and blood
glucose level of all animals in different groups varied depending on
treatment. Blood glucose test showed that there was a significant
increase in blood glucose level after induction. After treatment, the
normal group blood glucose level increased by 19.12 % but not
diabetic, and a decrease of 10.61 %, 61.64 %, 48.19 % and 77.16 % for
the Control, Standard, Test I and Test II respectively. The body weight
for normal group increased by 6.29 % while the Control group,
Standard group, Test I and Test II emaciated by 7.91 %, 3.35 %, 6.9 %
and 5.1 % respectively. The lipid profile test showed that Test I and
Test II groups have lower lipid values compare with other study
groups. Results from this study clearly indicated that the polyherbal
formula had hypoglycaemic and hypolipidemic effects on
Streptozotocin-induced diabetic rats.

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Aleshinloye,A. . (0000). HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS., 5 (), 16-16.

Aleshinloye,A. . "HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS." 5, no (), (0000): 16-16.

Aleshinloye,A. and . (0000). HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS., 5 (), pp16-16.

AleshinloyeA, . HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.. 0000, 5 ():16-16.

Aleshinloye,Abimbola Ololade , . "HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.", 5 . (0000) : 16-16.

A.Abimbola Ololade , "HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECTS OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS." vol.5, no., pp. 16-16, 0000.

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