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Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction

Authors: Shallie D, ADEJUMO Esther , Shotunde , Ihyar C, Adenuga Adebukola K

Publication Type: Journal article

Journal: International Journal Of Brain And Cognitive Sciences

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Abstract

Type II diabetes mellitus (DM2) has been associated with an increased risk of cognitive dysfunction and dementia through disease processes such as Alzheimer's disease and vascular dementia. While reduced glucose tolerance has deleterious effects on memory in the elderly and concomitant hippocampal atrophy. We investigated the impact of chronic intake of high and low alcohol on diabetes induced cognitive dysfunction. Adult male wistar rats were randomly divided into four groups of five rats each viz; GROUP 1- Normal control, were given rat pellets ad libitum; GROUP 2- Untreated diabetic, diabetes was induced with multiple dosages of alloxan per k/body weight. GROUP 3- Diabetic and low alcohol consumption, the rats in this group received multiple dosages of alloxan (as in group 2), followed by 9% w/w alcohol daily. GROUP 4- Diabetic and high alcohol consumption, the rats received multiple dosages of alcohol (as in group 2), and 20% w/w alcohol. At the end of the four weeks, rats in all the groups were subjected to Barne’s Maze test to assess their spatial memory. The rats were weighed and then euthanized by an overdose of chloroform. The skull was cut open and the brain excised and a portion of the prefrontal cortex taken and processed for the determination of some biochemical parameters. Sections of the brain were taken and processed routinely and stained with H&E. The results showed impairment of spatial memory, decrease psychomotor speed, neuronal necrosis and apparent decreased neuronal density. From our findings, we concluded that diabetes significantly impaired spatial memory and decrease psychomotor speed, while chronic alcohol intake ameliorated the detrimental cognitive dysfunctional. Both diabetes and alcohol operate probably by interfering with insulin sensitivity.

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Shallie,P.D ADEJUMO,E. Shotunde,D. Ihyar,A.C Adenuga,A.K . (0000). Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction, 2 (), 14-14.

Shallie,P.D ADEJUMO,E. Shotunde,D. Ihyar,A.C Adenuga,A.K . "Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction" 2, no (), (0000): 14-14.

Shallie,P.D and ADEJUMO,E. and Shotunde,D. and Ihyar,A.C and Adenuga,A.K and . (0000). Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction, 2 (), pp14-14.

ShalliePD, ADEJUMOE, ShotundeD, IhyarAC, AdenugaAK, . Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction. 0000, 2 ():14-14.

Shallie,Philemon D, ADEJUMO,Esther , Shotunde,Damilola , Ihyar,Ayenge C, and Adenuga,Adebukola K . "Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction", 2 . (0000) : 14-14.

S.Philemon D A.Esther S.Damilola I.Ayenge C & A.Adebukola K , "Moderate Chronic Alcohol Consumption Ameliorates Diabetes Induced Cognitive Dysfunction" vol.2, no., pp. 14-14, 0000.

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